| 10. Round | 24/10/2021 | NK Osijek II | - | NK Varaždin | 0:0 | ||||
| 12. Round | 07/11/2021 | NK Osijek II | - | NK Rudeš | 2:1 | ||||
| 11. Round | 12/11/2021 | NK Inter Zaprešić | - | NK Osijek II | 2:0 | ||||
| 13. Round | 19/11/2021 | NK Kustošija | - | NK Osijek II | 0:0 | ||||
| 14. Round | 27/11/2021 | NK Osijek II | - | NK Jarun | 0:0 |  |
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| 15. Round | 05/12/2021 | NK BSK Bijelo Brdo | - | NK Osijek II | 0:2 | ||||
| 16. Round | 12/02/2022 | NK Osijek II | - | NK Sesvete | 0:3 | ||||
| 17. Round | 20/02/2022 | Dinamo Zagreb II | - | NK Osijek II | 2:1 | |
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| 18. Round | 26/02/2022 | NK Osijek II | - | NK Dugopolje | 2:0 | ||||
| 19. Round | 05/03/2022 | NK Solin | - | NK Osijek II | 0:0 | ||||
| 20. Round | 14/03/2022 | NK Osijek II | - | NK Dubrava | 0:1 | ||||
| 21. Round | 20/03/2022 | NK Croatia Zmijavci | - | NK Osijek II | 1:0 | |
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| 23. Round | 09/04/2022 | NK Opatija | - | NK Osijek II | 1:2 | ||||
| 24. Round | 15/04/2022 | NK Osijek II | - | HNK Cibalia | 2:1 | ||||
| 25. Round | 23/04/2022 | NK Varaždin | - | NK Osijek II | 4:1 | ||||
| 27. Round | 07/05/2022 | NK Rudeš | - | NK Osijek II | 1:0 | ||||
| 29. Round | 21/05/2022 | NK Jarun | - | NK Osijek II | 3:0 |
Austria