| 26. Round | 04/08/2021 | Atlético Porteño | - | Independiente Juniors | 2:1 | ||||
| 27. Round | 10/08/2021 | Independiente Juniors | - | América de Quito | 1:2 |  |
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| 28. Round | 18/08/2021 | Gualaceo SC | - | Independiente Juniors | 2:0 | |
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| 29. Round | 24/08/2021 | Independiente Juniors | - | Atlético Santo Domingo | 1:1 | ||||
| 30. Round | 02/09/2021 | Guayaquil SC | - | Independiente Juniors | 0:0 | ||||
| 31. Round | 08/09/2021 | Liga de Portoviejo | - | Independiente Juniors | 0:1 | |
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| 32. Round | 15/09/2021 | Independiente Juniors | - | Chacaritas FC | 2:0 | ||||
| 33. Round | 24/09/2021 | Cumbayá | - | Independiente Juniors | 2:1 | ||||
| 34. Round | 30/09/2021 | Independiente Juniors | - | Atlético Porteño | 2:3 | ||||
| 35. Round | 06/10/2021 | América de Quito | - | Independiente Juniors | 1:1 | ||||
| 36. Round | 13/10/2021 | Independiente Juniors | - | El Nacional | 1:1 |
Ecuador