| 3. Round | 31/01/2021 | Nacional | - | Montevideo Wanderers | 2:1 | ||||
| 4. Round | 03/02/2021 | Peñarol | - | Nacional | 0:0 | ||||
| 5. Round | 08/02/2021 | Nacional | - | River Plate | 3:0 | ||||
| 6. Round | 11/02/2021 | Montevideo City Torque | - | Nacional | 1:2 | ||||
| 7. Round | 14/02/2021 | Nacional | - | Plaza Colonia | 1:1 | ||||
| 8. Round | 18/02/2021 | Progreso | - | Nacional | 0:1 | ||||
| 9. Round | 21/02/2021 | Nacional | - | Fénix | 2:2 | ||||
| 10. Round | 27/02/2021 | CA Cerro | - | Nacional | 0:1 | ||||
| 12. Round | 13/03/2021 | Danubio | - | Nacional | 2:1 | ||||
| 13. Round | 22/03/2021 | Nacional | - | Liverpool | 0:4 |  |
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| 14. Round | 25/03/2021 | Nacional | - | Boston River | 1:2 | |
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| 15. Round | 29/03/2021 | Deportivo Maldonado | - | Nacional | 1:2 |
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