| 16. Round | 19/08/2022 | CA Cerro | - | Villa Española | 1:1 | ||||
| 17. Round | 25/08/2022 | Juventud de Las Piedras | - | CA Cerro | 1:1 | ||||
| 18. Round | 28/08/2022 | CA Cerro | - | Racing | 0:0 | ||||
| 19. Round | 03/09/2022 | Rampla Juniors | - | CA Cerro | 2:2 | ||||
| 20. Round | 10/09/2022 | CA Cerro | - | Progreso | 1:1 | ||||
| 21. Round | 17/09/2022 | La Luz | - | CA Cerro | 0:1 |  |
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| 22. Round | 25/09/2022 | CA Cerro | - | Atenas | 0:4 |
Uruguay