| 2. Round | 21/02/2022 | Deportes Temuco | - | Santiago Wanderers | 1:0 | ||||
| 3. Round | 27/02/2022 | Deportes Iquique | - | Deportes Temuco | 1:0 | ||||
| 6. Round | 22/03/2022 | Puerto Montt | - | Deportes Temuco | 3:0 | ||||
| 7. Round | 05/04/2022 | Deportes Temuco | - | Santiago Morning | 2:1 |  |
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| 8. Round | 12/04/2022 | Rangers | - | Deportes Temuco | 3:2 | |
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| 9. Round | 16/04/2022 | Deportes Temuco | - | CD Magallanes | 2:4 | |
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| 12. Round | 30/04/2022 | San Luis | - | Deportes Temuco | 1:1 | |
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| 13. Round | 06/05/2022 | Deportes Temuco | - | Universidad de Concepción | 1:0 | |
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| 14. Round | 11/05/2022 | Recoleta | - | Deportes Temuco | 2:1 | ||||
| 15. Round | 17/05/2022 | Deportes Temuco | - | Cobreloa | 2:0 | |
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| 16. Round | 23/05/2022 | Barnechea | - | Deportes Temuco | 2:0 | ||||
| 17. Round | 29/05/2022 | Deportes Temuco | - | Deportes Copiapó | 0:4 | ||||
| 18. Round | 02/07/2022 | Deportes Temuco | - | Santa Cruz | 1:1 | |
Chile