| 1. Round | 05/02/2022 | Resistencia SC | - | Tacuary | 1:0 |  |
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| 2. Round | 11/02/2022 | Sportivo Ameliano | - | Resistencia SC | 1:4 |  |
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| 4. Round | 26/02/2022 | Guaraní | - | Resistencia SC | 3:3 | ||||
| 6. Round | 12/03/2022 | Sol de América | - | Resistencia SC | 1:1 | ||||
| 7. Round | 19/03/2022 | Resistencia SC | - | Cerro Porteño | 0:3 | ||||
| 8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
| 9. Round | 08/04/2022 | 12 de Octubre de Itauguá | - | Resistencia SC | 1:1 | ||||
| 11. Round | 21/04/2022 | Libertad | - | Resistencia SC | 2:2 | ||||
| 13. Round | 29/04/2022 | Resistencia SC | - | Sportivo Ameliano | 3:0 | ||||
| 14. Round | 06/05/2022 | Club Nacional | - | Resistencia SC | 1:2 |
Uruguay