| 1. Round | 10/07/2016 | General Díaz | - | General Caballero ZC | 0:0 | ||||
| 2. Round | 17/07/2016 | General Caballero ZC | - | Guaraní | 0:1 | ||||
| 3. Round | 21/07/2016 | Club Olimpia | - | General Caballero ZC | 0:0 | ||||
| 4. Round | 25/07/2016 | General Caballero ZC | - | Club Rubio Ñu | 1:1 | ||||
| 5. Round | 30/07/2016 | Sportivo Luqueño | - | General Caballero ZC | 2:2 | ||||
| 6. Round | 07/08/2016 | River Plate | - | General Caballero ZC | 1:1 | ||||
| 7. Round | 13/08/2016 | General Caballero ZC | - | Deportivo Capiatá | 1:2 | ||||
| 8. Round | 21/08/2016 | Cerro Porteño | - | General Caballero ZC | 1:2 | ||||
| 10. Round | 09/09/2016 | Club Nacional | - | General Caballero ZC | 4:1 | ||||
| 12. Round | 24/09/2016 | General Caballero ZC | - | General Díaz | 2:2 | ||||
| 13. Round | 01/10/2016 | Guaraní | - | General Caballero ZC | 2:1 |  |
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| 14. Round | 16/10/2016 | General Caballero ZC | - | Club Olimpia | 2:3 | |
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| 15. Round | 21/10/2016 | Club Rubio Ñu | - | General Caballero ZC | 0:1 | |
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| 16. Round | 28/10/2016 | General Caballero ZC | - | Sportivo Luqueño | 0:1 | ||||
| 17. Round | 05/11/2016 | General Caballero ZC | - | River Plate | 1:0 | ||||
| 18. Round | 18/11/2016 | Deportivo Capiatá | - | General Caballero ZC | 3:2 |
Paraguay