| 1. Round | 26/01/2025 | Cerro Porteño | - | Libertad | 2:2 |  |
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| 2. Round | 29/01/2025 | Club Nacional | - | Libertad | 0:3 | ||||
| 3. Round | 02/02/2025 | Libertad | - | Deportivo Recoleta | 5:2 | ||||
| 4. Round | 09/02/2025 | Guaraní | - | Libertad | 0:1 | |
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| 6. Round | 22/02/2025 | Atlético Tembetary | - | Libertad | 1:2 |  |
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| 7. Round | 28/02/2025 | Libertad | - | Sportivo Luqueño | 3:0 | ||||
| 8. Round | 08/03/2025 | Sportivo Trinidense | - | Libertad | 1:1 | |
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| 9. Round | 15/03/2025 | Libertad | - | Club Olimpia | 2:1 | |
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| 10. Round | 22/03/2025 | General Caballero DJLM | - | Libertad | 0:5 | |
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| 16. Round | 28/04/2025 | Sportivo Ameliano | - | Libertad | 0:0 | ||||
| 17. Round | 05/05/2025 | Libertad | - | Atlético Tembetary | 0:0 | ||||
| 18. Round | 11/05/2025 | Sportivo Luqueño | - | Libertad | 1:0 | |
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| 20. Round | 21/05/2025 | Club Olimpia | - | Libertad | 1:1 | |
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| 21. Round | 24/05/2025 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 22. Round | 01/06/2025 | 2 de Mayo | - | Libertad | 0:1 | |
Paraguay