| 1. Round | 30/04/2022 | Miramar Misiones | - | Progreso | 0:1 |  |
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| 2. Round | 07/05/2022 | Progreso | - | Villa Española | 2:0 | |
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| 3. Round | 16/05/2022 | Juventud de Las Piedras | - | Progreso | 0:0 | |
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| 4. Round | 22/05/2022 | Progreso | - | Racing | 0:2 | ||||
| 5. Round | 25/05/2022 | Rampla Juniors | - | Progreso | 1:1 | |
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| 6. Round | 28/05/2022 | Progreso | - | Uruguay Montevideo | 0:2 | ||||
| 11. Round | 25/06/2022 | Progreso | - | Central Español | 1:1 | ||||
| 12. Round | 23/07/2022 | Progreso | - | Miramar Misiones | 1:1 | |
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| 13. Round | 30/07/2022 | Villa Española | - | Progreso | 0:0 | ||||
| 14. Round | 06/08/2022 | Progreso | - | Juventud de Las Piedras | 0:1 | ||||
| 15. Round | 14/08/2022 | Racing | - | Progreso | 2:1 | ||||
| 16. Round | 20/08/2022 | Progreso | - | Rampla Juniors | 0:1 | |
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| 17. Round | 24/08/2022 | Uruguay Montevideo | - | Progreso | 1:0 | ||||
| 18. Round | 28/08/2022 | La Luz | - | Progreso | 1:1 | ||||
| 19. Round | 03/09/2022 | Progreso | - | Atenas | 1:0 | ||||
| 21. Round | 17/09/2022 | Progreso | - | Sud América | 3:1 | ||||
| 22. Round | 25/09/2022 | Central Español | - | Progreso | 1:1 | |
Uruguay