| 1. Round | 16/07/2021 | Independiente II | - | Argentinos Juniors II | 3:0 | ||||
| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 3. Round | 27/07/2021 | Arsenal de Sarandí II | - | Argentinos Juniors II | 3:1 | ||||
| 4. Round | 02/08/2021 | Argentinos Juniors II | - | Central Córdoba SdE II | 1:0 | ||||
| 5. Round | 06/08/2021 | Boca Juniors II | - | Argentinos Juniors II | 0:1 | ||||
| 6. Round | 13/08/2021 | Argentinos Juniors II | - | Banfield II | 0:0 | ||||
| 18. Round | 26/10/2021 | River Plate II | - | Argentinos Juniors II | 0:3 | ||||
| 19. Round | 01/11/2021 | Argentinos Juniors II | - | Lanús II | 2:1 | ||||
| 20. Round | 09/11/2021 | Huracán II | - | Argentinos Juniors II | 1:0 | ||||
| 22. Round | 25/11/2021 | Vélez Sarsfield II | - | Argentinos Juniors II | 1:1 | ||||
| 23. Round | 30/11/2021 | Argentinos Juniors II | - | Gimnasia de La Plata II | 1:2 | ||||
| 24. Round | 04/12/2021 | Aldosivi II | - | Argentinos Juniors II | 2:2 | ||||
| 25. Round | 11/12/2021 | Argentinos Juniors II | - | Sarmiento de Junín II | 1:2 |
Argentina