11. Round | 03/10/2021 | Guaraní | - | Club Nacional | 1:1 | ||||
12. Round | 18/10/2021 | 12 de Octubre de Itauguá | - | Guaraní | 1:2 | ||||
15. Round | 07/11/2021 | Libertad | - | Guaraní | 2:0 | ||||
16. Round | 20/11/2021 | Guaraní | - | River Plate | 2:1 | ||||
17. Round | 28/11/2021 | Guaireña FC | - | Guaraní | 1:1 | ||||
18. Round | 04/12/2021 | Guaraní | - | Cerro Porteño | 2:2 |