| 1. Round | 15/02/2021 | Estudiantes | - | River Plate | 2:1 |  |
|||
| 2. Round | 21/02/2021 | River Plate | - | Rosario Central | 3:0 | ||||
| 3. Round | 28/02/2021 | Platense | - | River Plate | 0:1 | |
|||
| 4. Round | 09/03/2021 | River Plate | - | Argentinos Juniors | 0:1 |  |
|||
| 5. Round | 14/03/2021 | Boca Juniors | - | River Plate | 1:1 | ||||
| 6. Round | 21/03/2021 | Godoy Cruz | - | River Plate | 1:6 | |
|||
| 7. Round | 28/03/2021 | River Plate | - | Racing Club | 0:0 | ||||
| 8. Round | 04/04/2021 | Arsenal de Sarandí | - | River Plate | 0:0 | |
|||
| 13. Round | 09/05/2021 | River Plate | - | Aldosivi | 4:1 | |
Argentina
Belgium