| 19. Round | 19/01/2025 | Almere City FC | - | Heracles Almelo | 0:2 |  |
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| 20. Round | 24/01/2025 | Heracles Almelo | - | FC Utrecht | 1:1 | ||||
| 21. Round | 31/01/2025 | NAC Breda | - | Heracles Almelo | 1:1 | ||||
| 22. Round | 08/02/2025 | Heracles Almelo | - | Go Ahead Eagles | 4:2 | ||||
| 23. Round | 16/02/2025 | AFC Ajax | - | Heracles Almelo | 4:0 | ||||
| 24. Round | 02/03/2025 | Heracles Almelo | - | PEC Zwolle | 4:2 | ||||
| 25. Round | 08/03/2025 | Fortuna Sittard | - | Heracles Almelo | 1:0 | ||||
| 26. Round | 15/03/2025 | sc Heerenveen | - | Heracles Almelo | 1:1 | ||||
| 28. Round | 06/04/2025 | RKC Waalwijk | - | Heracles Almelo | 0:0 | ||||
| 29. Round | 13/04/2025 | Heracles Almelo | - | AZ Alkmaar | 1:0 | ||||
| 30. Round | 23/04/2025 | FC Groningen | - | Heracles Almelo | 4:1 | ||||
| 31. Round | 03/05/2025 | Heracles Almelo | - | Feyenoord | 1:4 | ||||
| 32. Round | 09/05/2025 | Willem II | - | Heracles Almelo | 1:2 |
Netherlands