| 1. Round | 06/08/2022 | Fortuna Sittard | - | AFC Ajax | 2:3 |  |
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| 2. Round | 14/08/2022 | FC Twente | - | Fortuna Sittard | 3:0 | |
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| 3. Round | 20/08/2022 | Fortuna Sittard | - | SC Cambuur | 1:4 | |
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| 4. Round | 27/08/2022 | sc Heerenveen | - | Fortuna Sittard | 2:1 | ||||
| 5. Round | 02/09/2022 | Fortuna Sittard | - | FC Utrecht | 3:4 | ||||
| 6. Round | 10/09/2022 | NEC Nijmegen | - | Fortuna Sittard | 1:1 | ||||
| 7. Round | 17/09/2022 | Fortuna Sittard | - | SBV Excelsior | 1:0 |  |
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| 9. Round | 09/10/2022 | Vitesse | - | Fortuna Sittard | 1:2 | ||||
| 10. Round | 15/10/2022 | Fortuna Sittard | - | RKC Waalwijk | 0:0 | ||||
| 11. Round | 22/10/2022 | Feyenoord | - | Fortuna Sittard | 1:1 | ||||
| 12. Round | 29/10/2022 | Sparta Rotterdam | - | Fortuna Sittard | 3:1 | ||||
| 13. Round | 05/11/2022 | Fortuna Sittard | - | FC Emmen | 0:1 |
Netherlands