| 2. Round | 22/01/2022 | Alacranes de Durango | - | Saltillo FC | 3:1 |  |
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| 4. Round | 05/02/2022 | Correcaminos UAT II | - | Saltillo FC | 1:1 | ||||
| 6. Round | 19/02/2022 | Saltillo FC | - | Catedráticos Elite | 3:0 | ||||
| 1. Round | 02/03/2022 | Saltillo FC | - | Tuzos de la UAZ | 1:0 | ||||
| 10. Round | 19/03/2022 | Saltillo FC | - | Colima FC | 2:1 |
Mexico