| 1. Round | 08/08/2020 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:2 | ||||
| 2. Round | 11/08/2020 | Slovan Bratislava | - | MFK Zemplín Michalovce | 5:0 | ||||
| 3. Round | 15/08/2020 | FK Senica | - | MFK Zemplín Michalovce | 3:0 |  |
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| 4. Round | 25/08/2020 | MFK Zemplín Michalovce | - | Zlaté Moravce | 1:0 | ||||
| 5. Round | 30/08/2020 | MŠK Žilina | - | MFK Zemplín Michalovce | 6:2 |  |
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| 6. Round | 12/09/2020 | MFK Zemplín Michalovce | - | AS Trenčín | 1:1 | ||||
| 7. Round | 19/09/2020 | MFK Ružomberok | - | MFK Zemplín Michalovce | 4:0 | ||||
| 12. Round | 31/10/2020 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:2 | ||||
| 13. Round | 07/11/2020 | MFK Zemplín Michalovce | - | Slovan Bratislava | 0:2 | ||||
| 14. Round | 21/11/2020 | MFK Zemplín Michalovce | - | FK Senica | 0:1 | |
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| 15. Round | 28/11/2020 | Zlaté Moravce | - | MFK Zemplín Michalovce | 0:0 | ||||
| 16. Round | 05/12/2020 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:1 | ||||
| 17. Round | 13/12/2020 | AS Trenčín | - | MFK Zemplín Michalovce | 2:2 | |
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| 18. Round | 16/12/2020 | MFK Zemplín Michalovce | - | MFK Ružomberok | 4:3 | ||||
| 20. Round | 20/02/2021 | MFK Zemplín Michalovce | - | ŠKF Sereď | 0:2 | |
Slovakia