| 12. Round | 17/01/2021 | Gavilanes de Matamoros | - | Colima FC | 0:0 | ||||
| 13. Round | 23/01/2021 | Tuzos de la UAZ | - | Gavilanes de Matamoros | 2:0 | ||||
| 17. Round | 22/02/2021 | Leones Negros II | - | Gavilanes de Matamoros | 0:1 | ||||
| 18. Round | 06/03/2021 | Gavilanes de Matamoros | - | Tecos Fútbol Club | 1:0 | ||||
| 19. Round | 13/03/2021 | Mineros de Fresnillo FC | - | Gavilanes de Matamoros | 1:1 | ||||
| 20. Round | 20/03/2021 | Gavilanes de Matamoros | - | Mazorqueros | 1:0 | ||||
| 21. Round | 03/04/2021 | Atlético San Luis II | - | Gavilanes de Matamoros | 1:1 |
Mexico