| 1. Round | 16/01/2021 | Danubio | - | Cerro Largo | 0:3 | ||||
| 5. Round | 07/02/2021 | Danubio | - | Montevideo City Torque | 0:4 | ||||
| 8. Round | 18/02/2021 | Fénix | - | Danubio | 1:1 |  |
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| 9. Round | 22/02/2021 | Danubio | - | CA Cerro | 2:1 | |
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| 10. Round | 28/02/2021 | Defensor Sporting | - | Danubio | 1:1 | |
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| 12. Round | 13/03/2021 | Danubio | - | Nacional | 2:1 | ||||
| 13. Round | 19/03/2021 | Boston River | - | Danubio | 1:5 | ||||
| 14. Round | 23/03/2021 | Danubio | - | Deportivo Maldonado | 2:2 | ||||
| 15. Round | 29/03/2021 | Rentistas | - | Danubio | 1:0 |
Uruguay