| 1. Round | 30/04/2022 | Villa Española | - | Rampla Juniors | 3:2 | ||||
| 2. Round | 08/05/2022 | Rampla Juniors | - | Juventud de Las Piedras | 0:1 | ||||
| 3. Round | 15/05/2022 | Racing | - | Rampla Juniors | 1:0 | ||||
| 4. Round | 21/05/2022 | Rampla Juniors | - | Uruguay Montevideo | 1:2 |  |
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| 5. Round | 25/05/2022 | Rampla Juniors | - | Progreso | 1:1 | |
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| 6. Round | 29/05/2022 | La Luz | - | Rampla Juniors | 2:0 | |
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| 8. Round | 12/06/2022 | CA Cerro | - | Rampla Juniors | 1:0 | ||||
| 9. Round | 18/06/2022 | Rampla Juniors | - | Sud América | 0:0 | |
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| 10. Round | 23/06/2022 | Central Español | - | Rampla Juniors | 2:0 | ||||
| 11. Round | 26/06/2022 | Rampla Juniors | - | Miramar Misiones | 1:2 | ||||
| 12. Round | 24/07/2022 | Rampla Juniors | - | Villa Española | 1:0 | ||||
| 13. Round | 31/07/2022 | Juventud de Las Piedras | - | Rampla Juniors | 1:2 | ||||
| 18. Round | 29/08/2022 | Atenas | - | Rampla Juniors | 1:1 | ||||
| 21. Round | 18/09/2022 | Rampla Juniors | - | Central Español | 3:0 | ||||
| 22. Round | 25/09/2022 | Miramar Misiones | - | Rampla Juniors | 1:3 |
Argentina