| 4. Round | 15/02/2010 | Colón de Santa Fe | - | River Plate | 1:0 |  |
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| 7. Round | 04/03/2010 | River Plate | - | San Lorenzo | 1:0 | ||||
| 8. Round | 07/03/2010 | Independiente | - | River Plate | 2:0 | |
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| 9. Round | 14/03/2010 | River Plate | - | Huracán | 2:0 | ||||
| 11. Round | 30/03/2010 | River Plate | - | Argentinos Juniors | 0:1 | ||||
| 13. Round | 07/04/2010 | River Plate | - | Newell's Old Boys | 0:1 | ||||
| 14. Round | 12/04/2010 | Atlético Tucumán | - | River Plate | 0:0 | ||||
| 16. Round | 24/04/2010 | Estudiantes | - | River Plate | 1:0 | ||||
| 17. Round | 01/05/2010 | River Plate | - | Vélez Sarsfield | 2:1 | ||||
| 18. Round | 08/05/2010 | Racing Club | - | River Plate | 0:3 | ||||
| 19. Round | 15/05/2010 | River Plate | - | Tigre | 1:5 |
Uruguay
USA