| 1. Round | 01/02/2025 | Danubio | - | Liverpool | 1:1 | ||||
| 2. Round | 09/02/2025 | Juventud de Las Piedras | - | Danubio | 2:2 | ||||
| 3. Round | 15/02/2025 | Danubio | - | Cerro Largo | 0:0 | ||||
| 4. Round | 23/02/2025 | Danubio | - | Progreso | 1:1 | ||||
| 5. Round | 10/03/2025 | Miramar Misiones | - | Danubio | 1:0 | ||||
| 6. Round | 16/03/2025 | Danubio | - | Montevideo Wanderers | 2:2 | ||||
| 7. Round | 23/03/2025 | CA Cerro | - | Danubio | 1:1 |  |
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| 8. Round | 27/03/2025 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 9. Round | 30/03/2025 | Montevideo City Torque | - | Danubio | 1:1 | ||||
| 10. Round | 05/04/2025 | Danubio | - | Peñarol | 0:1 | ||||
| 11. Round | 13/04/2025 | Nacional | - | Danubio | 2:0 | ||||
| 12. Round | 18/04/2025 | Danubio | - | Boston River | 1:2 | ||||
| 13. Round | 26/04/2025 | River Plate | - | Danubio | 1:0 | ||||
| 14. Round | 03/05/2025 | Danubio | - | Racing | 0:0 |
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