| 1. Round | 13/09/2020 | FC Groningen | - | PSV Eindhoven | 1:3 | ||||
| 2. Round | 19/09/2020 | PSV Eindhoven | - | FC Emmen | 2:1 | ||||
| 3. Round | 27/09/2020 | Heracles Almelo | - | PSV Eindhoven | 1:1 | ||||
| 4. Round | 04/10/2020 | PSV Eindhoven | - | Fortuna Sittard | 2:0 | ||||
| 5. Round | 18/10/2020 | PEC Zwolle | - | PSV Eindhoven | 0:3 | ||||
| 6. Round | 25/10/2020 | Vitesse | - | PSV Eindhoven | 2:1 | ||||
| 7. Round | 01/11/2020 | PSV Eindhoven | - | ADO Den Haag | 4:0 | ||||
| 8. Round | 08/11/2020 | PSV Eindhoven | - | Willem II | 3:0 | ||||
| 9. Round | 22/11/2020 | FC Twente | - | PSV Eindhoven | 1:1 | ||||
| 10. Round | 29/11/2020 | PSV Eindhoven | - | Sparta Rotterdam | 1:0 | ||||
| 15. Round | 10/01/2021 | AFC Ajax | - | PSV Eindhoven | 2:2 | ||||
| 16. Round | 13/01/2021 | PSV Eindhoven | - | AZ Alkmaar | 1:3 | ||||
| 17. Round | 16/01/2021 | Sparta Rotterdam | - | PSV Eindhoven | 3:5 |  |
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| 18. Round | 23/01/2021 | PSV Eindhoven | - | RKC Waalwijk | 2:0 | ||||
| 19. Round | 26/01/2021 | FC Emmen | - | PSV Eindhoven | 0:2 | |
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| 20. Round | 31/01/2021 | Feyenoord | - | PSV Eindhoven | 3:1 |  |
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| 21. Round | 06/02/2021 | PSV Eindhoven | - | FC Twente | 3:0 | ||||
| 22. Round | 13/02/2021 | ADO Den Haag | - | PSV Eindhoven | 2:2 | ||||
| 23. Round | 21/02/2021 | PSV Eindhoven | - | Vitesse | 3:1 |
Brazil