1. Round | 15/02/2022 | Santa Cruz | - | Deportes Temuco | 1:1 | ||||
3. Round | 01/03/2022 | Santa Cruz | - | CD Magallanes | 1:2 | ||||
4. Round | 07/03/2022 | Fernández Vial | - | Santa Cruz | 1:0 | ||||
6. Round | 23/03/2022 | Santa Cruz | - | Barnechea | 1:1 | ||||
7. Round | 03/04/2022 | Deportes Iquique | - | Santa Cruz | 2:2 | ||||
8. Round | 11/04/2022 | Santa Cruz | - | Universidad de Concepción | 0:0 | ||||
10. Round | 21/04/2022 | Rangers | - | Santa Cruz | 2:1 | ||||
11. Round | 26/04/2022 | Santa Cruz | - | Copiapó | 2:2 | ||||
13. Round | 08/05/2022 | Santa Cruz | - | Recoleta | 1:0 | ||||
14. Round | 12/05/2022 | Unión San Felipe | - | Santa Cruz | 2:1 | ||||
16. Round | 22/05/2022 | Melipilla | - | Santa Cruz | 1:0 | ||||
5. Round | 02/06/2022 | Cobreloa | - | Santa Cruz | 1:0 |