| 1. Round | 08/08/2021 | ADO Den Haag | - | Jong Ajax | 2:0 | ||||
| 2. Round | 16/08/2021 | Jong Ajax | - | FC Dordrecht | 1:2 |  |
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| 3. Round | 20/08/2021 | FC Den Bosch | - | Jong Ajax | 2:3 | |
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| 4. Round | 27/08/2021 | Jong Ajax | - | SBV Excelsior | 1:2 | ||||
| 6. Round | 10/09/2021 | Jong PSV | - | Jong Ajax | 3:1 | ||||
| 5. Round | 13/09/2021 | Jong Ajax | - | NAC Breda | 6:3 | |
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| 7. Round | 17/09/2021 | Almere City FC | - | Jong Ajax | 2:4 | |
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| 8. Round | 27/09/2021 | Jong Ajax | - | MVV | 3:1 | ||||
| 9. Round | 01/10/2021 | Helmond Sport | - | Jong Ajax | 3:1 | ||||
| 11. Round | 15/10/2021 | Jong Ajax | - | FC Utrecht (J) | 3:1 | ||||
| 10. Round | 18/10/2021 | AZ Alkmaar (J) | - | Jong Ajax | 1:1 | |
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| 12. Round | 22/10/2021 | FC Eindhoven | - | Jong Ajax | 1:3 | ||||
| 13. Round | 01/11/2021 | Jong Ajax | - | Telstar | 3:0 | ||||
| 14. Round | 05/11/2021 | VVV-Venlo | - | Jong Ajax | 1:3 | ||||
| 16. Round | 19/11/2021 | Jong Ajax | - | FC Volendam | 4:4 | |
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| 15. Round | 22/11/2021 | Jong Ajax | - | Roda JC Kerkrade | 2:1 | ||||
| 17. Round | 26/11/2021 | De Graafschap | - | Jong Ajax | 1:3 | ||||
| 18. Round | 06/12/2021 | Jong Ajax | - | FC Emmen | 1:0 | ||||
| 19. Round | 10/12/2021 | TOP Oss | - | Jong Ajax | 1:1 | ||||
| 20. Round | 20/12/2021 | Jong Ajax | - | Helmond Sport | 1:1 |
Netherlands