| 1. Round | 27/08/2021 | PSV Eindhoven [Women] | - | PEC Zwolle [Women] | 3:0 |  |
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| 4. Round | 26/09/2021 | PSV Eindhoven [Women] | - | FC Twente [Women] | 2:1 | ||||
| 5. Round | 01/10/2021 | ADO Den Haag [Women] | - | PSV Eindhoven [Women] | 1:0 | ||||
| 6. Round | 08/10/2021 | PSV Eindhoven [Women] | - | sc Heerenveen [Women] | 4:1 | ||||
| 7. Round | 17/10/2021 | Feyenoord [Women] | - | PSV Eindhoven [Women] | 2:1 | ||||
| 9. Round | 07/11/2021 | AFC Ajax [Women] | - | PSV Eindhoven [Women] | 5:1 | ||||
| 13. Round | 12/12/2021 | sc Heerenveen [Women] | - | PSV Eindhoven [Women] | 0:1 |
Netherlands