| 4. Round | 04/02/2021 | River Plate | - | Danubio | 0:4 | ||||
| 6. Round | 11/02/2021 | River Plate | - | Boston River | 3:1 | ||||
| 7. Round | 14/02/2021 | Deportivo Maldonado | - | River Plate | 1:2 | ||||
| 8. Round | 17/02/2021 | River Plate | - | Rentistas | 1:1 | ||||
| 9. Round | 20/02/2021 | River Plate | - | Cerro Largo | 2:0 |  |
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| 11. Round | 06/03/2021 | Peñarol | - | River Plate | 2:0 | |
Uruguay