| 8. Round | 04/10/2015 | Nacional | - | Defensor Sporting | 4:0 | ||||
| 9. Round | 17/10/2015 | Defensor Sporting | - | Montevideo Wanderers | 2:3 |  |
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| 10. Round | 24/10/2015 | Plaza Colonia | - | Defensor Sporting | 0:0 | ||||
| 11. Round | 31/10/2015 | Defensor Sporting | - | Juventud de Las Piedras | 4:1 | |
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| 12. Round | 07/11/2015 | CA Cerro | - | Defensor Sporting | 2:3 | ||||
| 13. Round | 20/11/2015 | Defensor Sporting | - | El Tanque Sisley | 2:2 | |
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| 14. Round | 27/11/2015 | Defensor Sporting | - | River Plate | 1:2 | ||||
| 15. Round | 05/12/2015 | Fénix | - | Defensor Sporting | 3:0 |
Uruguay