| 6. Round | 16/03/2025 | Juventud de Las Piedras | - | Defensor Sporting | 2:1 | ||||
| 7. Round | 23/03/2025 | Defensor Sporting | - | Cerro Largo | 0:0 | ||||
| 8. Round | 27/03/2025 | Danubio | - | Defensor Sporting | 1:1 | ||||
| 9. Round | 01/04/2025 | Defensor Sporting | - | Miramar Misiones | 2:0 |  |
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| 10. Round | 07/04/2025 | Montevideo Wanderers | - | Defensor Sporting | 0:0 | ||||
| 11. Round | 14/04/2025 | Defensor Sporting | - | CA Cerro | 3:2 |  |
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| 12. Round | 20/04/2025 | Defensor Sporting | - | Progreso | 1:2 | |
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| 13. Round | 27/04/2025 | Montevideo City Torque | - | Defensor Sporting | 0:1 | |
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| 14. Round | 03/05/2025 | Defensor Sporting | - | Peñarol | 0:1 | ||||
| 15. Round | 18/05/2025 | Nacional | - | Defensor Sporting | 2:1 |
Uruguay