| 1. Round | 28/07/2020 | Mazatlán FC | - | Puebla FC | 1:4 | ||||
| 2. Round | 01/08/2020 | Puebla FC | - | Cruz Azul | 1:1 | ||||
| 3. Round | 09/08/2020 | Deportivo Guadalajara | - | Puebla FC | 0:1 | ||||
| 4. Round | 12/08/2020 | UANL Tigres | - | Puebla FC | 2:1 | ||||
| 5. Round | 15/08/2020 | Puebla FC | - | CF Pachuca | 0:1 | ||||
| 6. Round | 24/08/2020 | Club Tijuana | - | Puebla FC | 1:0 | ||||
| 7. Round | 29/08/2020 | Puebla FC | - | Deportivo Toluca | 4:1 | ||||
| 8. Round | 05/09/2020 | Pumas UNAM | - | Puebla FC | 4:1 | ||||
| 9. Round | 09/09/2020 | Puebla FC | - | CF América | 2:3 | ||||
| 10. Round | 12/09/2020 | FC Juárez | - | Puebla FC | 1:0 |  |
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| 11. Round | 19/09/2020 | Club Necaxa | - | Puebla FC | 0:1 | ||||
| 12. Round | 26/09/2020 | Puebla FC | - | Gallos Blancos | 3:3 | ||||
| 14. Round | 17/10/2020 | CF Monterrey | - | Puebla FC | 3:1 | ||||
| 15. Round | 24/10/2020 | Puebla FC | - | Club León | 1:2 | |
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| 16. Round | 31/10/2020 | Atlas Guadalajara | - | Puebla FC | 0:1 | ||||
| 17. Round | 07/11/2020 | Puebla FC | - | Atlético San Luis | 1:0 |
Uruguay