| 1. Round | 11/09/2021 | River Plate | - | Cerrito | 1:0 | ||||
| 2. Round | 18/09/2021 | Cerrito | - | Cerro Largo | 1:1 | ||||
| 3. Round | 26/09/2021 | Progreso | - | Cerrito | 0:1 |  |
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| 4. Round | 02/10/2021 | Cerrito | - | Sud América | 2:0 | |
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| 5. Round | 11/10/2021 | Plaza Colonia | - | Cerrito | 3:3 | |
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| 6. Round | 17/10/2021 | Cerrito | - | Fénix | 2:4 | |
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| 7. Round | 21/10/2021 | Boston River | - | Cerrito | 3:2 | |
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| 8. Round | 24/10/2021 | Cerrito | - | Montevideo Wanderers | 2:2 | |
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| 9. Round | 29/10/2021 | Rentistas | - | Cerrito | 1:2 | ||||
| 10. Round | 05/11/2021 | Cerrito | - | Peñarol | 1:3 | |
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| 11. Round | 07/11/2021 | Cerrito | - | Montevideo City Torque | 0:2 | ||||
| 12. Round | 13/11/2021 | Cerrito | - | Villa Española | 1:0 | ||||
| 13. Round | 19/11/2021 | Nacional | - | Cerrito | 1:0 | ||||
| 14. Round | 25/11/2021 | Deportivo Maldonado | - | Cerrito | 0:1 | ||||
| 15. Round | 06/12/2021 | Cerrito | - | Liverpool | 2:1 | |
Uruguay