| 2. Round | 20/01/2025 | CF Pachuca [U19] | - | Santos Laguna [U19] | 2:1 | ||||
| 3. Round | 25/01/2025 | Santos Laguna [U19] | - | CF América [U19] | 3:0 |  |
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| 4. Round | 29/01/2025 | FC Juárez [U19] | - | Santos Laguna [U19] | 0:1 | ||||
| 5. Round | 02/02/2025 | Santos Laguna [U19] | - | Puebla FC [U19] | 2:0 | |
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| 8. Round | 23/02/2025 | Santos Laguna [U19] | - | Atlas Guadalajara [U19] | 1:2 | ||||
| 10. Round | 02/03/2025 | CF Monterrey [U19] | - | Santos Laguna [U19] | 1:0 | ||||
| 11. Round | 09/03/2025 | Santos Laguna [U19] | - | Club León [U19] | 2:1 | ||||
| 12. Round | 15/03/2025 | UANL Tigres [U19] | - | Santos Laguna [U19] | 3:1 | |
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| 15. Round | 18/03/2025 | Santos Laguna [U19] | - | Gallos Blancos [U19] | 4:2 | ||||
| 16. Round | 22/03/2025 | Pumas UNAM [U19] | - | Santos Laguna [U19] | 3:2 | ||||
| 13. Round | 30/03/2025 | Santos Laguna [U19] | - | Atlético San Luis [U19] | 2:1 | |
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| 14. Round | 06/04/2025 | Deportivo Toluca [U19] | - | Santos Laguna [U19] | 0:2 |
Mexico