| 6. Round | 19/09/2021 | Austin FC | - | San Jose Earthquakes | 3:4 | ||||
| 6. Round | 27/09/2021 | Austin FC | - | Los Angeles Galaxy | 2:0 |  |
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| 6. Round | 30/09/2021 | Colorado Rapids | - | Austin FC | 3:0 |  |
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| 7. Round | 02/10/2021 | Austin FC | - | Real Salt Lake | 2:1 | ||||
| 7. Round | 17/10/2021 | Austin FC | - | Minnesota United FC | 0:1 | ||||
| 7. Round | 21/10/2021 | San Jose Earthquakes | - | Austin FC | 4:0 | ||||
| 7. Round | 24/10/2021 | Austin FC | - | Houston Dynamo | 2:1 | ||||
| 7. Round | 31/10/2021 | FC Dallas | - | Austin FC | 2:1 | ||||
| 8. Round | 04/11/2021 | Austin FC | - | Sporting Kansas City | 3:1 |
USA