| 1. Round | 29/08/2021 | FC Annecy [Youth B] | - | SAS Épinal [Youth B] | 2:1 |  |
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| 2. Round | 05/09/2021 | SAS Épinal [Youth B] | - | Dijon FCO [Youth B] | 1:1 | |
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| 3. Round | 12/09/2021 | FC Mulhouse [Youth B] | - | SAS Épinal [Youth B] | 2:0 | ||||
| 4. Round | 19/09/2021 | FC Lyon [Youth B] | - | SAS Épinal [Youth B] | 2:0 | ||||
| 5. Round | 26/09/2021 | SAS Épinal [Youth B] | - | AS Nancy Lorraine [Youth B] | 0:3 | ||||
| 6. Round | 03/10/2021 | RC Strasbourg [Youth B] | - | SAS Épinal [Youth B] | 3:0 | ||||
| 7. Round | 10/10/2021 | SAS Épinal [Youth B] | - | ASPTT Dijon [Youth B] | 0:3 | ||||
| 8. Round | 17/10/2021 | FC Bourg-Péronnas [Youth B] | - | SAS Épinal [Youth B] | 2:0 | ||||
| 10. Round | 14/11/2021 | AJ Auxerre [Youth B] | - | SAS Épinal [Youth B] | 3:0 | ||||
| 11. Round | 21/11/2021 | SAS Épinal [Youth B] | - | FC Metz [Youth B] | 0:5 |
France
Algeria