| 1. Round | 26/03/2022 | El Nacional [Women] | - | Guayaquil City [Women] | 2:0 |  |
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| 2. Round | 02/04/2022 | LDU Quito [Women] | - | El Nacional [Women] | 4:2 | ||||
| 3. Round | 16/04/2022 | El Nacional [Women] | - | Técnico Universitario [Women] | 0:0 | ||||
| 4. Round | 23/04/2022 | Barcelona [Women] | - | El Nacional [Women] | 12:0 | ||||
| 7. Round | 14/05/2022 | El Nacional [Women] | - | Universidad Católica [Women] | 0:2 |  |
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| 8. Round | 22/05/2022 | Guayaquil City [Women] | - | El Nacional [Women] | 1:2 | ||||
| 9. Round | 28/05/2022 | El Nacional [Women] | - | LDU Quito [Women] | 2:5 | ||||
| 11. Round | 11/06/2022 | El Nacional [Women] | - | Barcelona [Women] | 0:2 | ||||
| 12. Round | 24/07/2022 | UPS Carneras [Women] | - | El Nacional [Women] | 3:0 | |
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| 13. Round | 30/07/2022 | El Nacional [Women] | - | Deportivo Ibarra [Women] | 2:3 | ||||
| 14. Round | 06/08/2022 | Universidad Católica [Women] | - | El Nacional [Women] | 1:2 | |
Ecuador