| 1. Round | 16/03/2022 | Chacaritas FC | - | Búhos ULVR | 2:0 | ||||
| 2. Round | 24/03/2022 | Libertad de Loja | - | Chacaritas FC | 5:1 |  |
|||
| 3. Round | 27/03/2022 | Chacaritas FC | - | El Nacional | 3:2 | ||||
| 4. Round | 01/04/2022 | Independiente Juniors | - | Chacaritas FC | 1:0 | ||||
| 5. Round | 07/04/2022 | Chacaritas FC | - | Olmedo | 1:0 | ||||
| 6. Round | 13/04/2022 | Chacaritas FC | - | Imbabura | 2:1 | ||||
| 7. Round | 19/04/2022 | América de Quito | - | Chacaritas FC | 1:1 |  |
|||
| 9. Round | 05/05/2022 | Manta | - | Chacaritas FC | 1:1 | |
|||
| 10. Round | 11/05/2022 | Chacaritas FC | - | Libertad de Loja | 1:0 |  |
|||
| 13. Round | 04/06/2022 | Olmedo | - | Chacaritas FC | 1:1 | ||||
| 14. Round | 08/06/2022 | Imbabura | - | Chacaritas FC | 0:2 | ||||
| 24. Round | 27/08/2022 | Chacaritas FC | - | Búhos ULVR | 1:0 | ||||
| 29. Round | 24/09/2022 | Chacaritas FC | - | América de Quito | 0:2 | |
|||
| 30. Round | 28/09/2022 | Olmedo | - | Chacaritas FC | 1:0 | ||||
| 31. Round | 02/10/2022 | Chacaritas FC | - | Atlético Santo Domingo | 3:0 | ||||
| 32. Round | 06/10/2022 | Búhos ULVR | - | Chacaritas FC | 1:1 | ||||
| 33. Round | 12/10/2022 | Chacaritas FC | - | Independiente Juniors | 0:1 | ||||
| 34. Round | 19/10/2022 | Manta | - | Chacaritas FC | 3:1 | |
Ecuador