| 2. Round | 20/09/2020 | Willem II | - | Heracles Almelo | 4:0 | ||||
| 3. Round | 27/09/2020 | Heracles Almelo | - | PSV Eindhoven | 1:1 | ||||
| 4. Round | 03/10/2020 | Vitesse | - | Heracles Almelo | 3:0 | ||||
| 5. Round | 17/10/2020 | Heracles Almelo | - | RKC Waalwijk | 0:1 | ||||
| 6. Round | 25/10/2020 | Sparta Rotterdam | - | Heracles Almelo | 1:1 | ||||
| 9. Round | 22/11/2020 | AFC Ajax | - | Heracles Almelo | 5:0 | ||||
| 10. Round | 29/11/2020 | Heracles Almelo | - | AZ Alkmaar | 1:2 |
Netherlands