| 1. Round | 11/07/2022 | Barcelona | - | Delfín SC | 0:1 | ||||
| 2. Round | 17/07/2022 | Técnico Universitario | - | Barcelona | 0:2 |  |
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| 3. Round | 25/07/2022 | Barcelona | - | 9 de Octubre | 2:2 | ||||
| 4. Round | 31/07/2022 | Independiente del Valle | - | Barcelona | 1:1 | ||||
| 5. Round | 08/08/2022 | Barcelona | - | Mushuc Runa | 4:1 |  |
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| 6. Round | 14/08/2022 | Barcelona | - | Universidad Catolica | 0:0 | ||||
| 7. Round | 20/08/2022 | Orense SC | - | Barcelona | 1:2 | ||||
| 8. Round | 29/08/2022 | Barcelona | - | LDU Quito | 1:1 | |
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| 9. Round | 04/09/2022 | Gualaceo SC | - | Barcelona | 2:1 | ||||
| 10. Round | 11/09/2022 | Barcelona | - | Macará | 5:3 | |
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| 11. Round | 19/09/2022 | Emelec | - | Barcelona | 1:3 | ||||
| 12. Round | 03/10/2022 | Barcelona | - | Guayaquil City | 1:1 | ||||
| 13. Round | 09/10/2022 | Deportivo Cuenca | - | Barcelona | 2:1 |  |
Ecuador