| 1. Round | 29/07/2020 | CF Monterrey | - | Deportivo Toluca | 3:1 | ||||
| 2. Round | 02/08/2020 | Deportivo Toluca | - | Atlético San Luis | 3:2 |  |
|||
| 3. Round | 08/08/2020 | Mazatlán FC | - | Deportivo Toluca | 2:1 | |
|||
| 4. Round | 14/08/2020 | Atlas Guadalajara | - | Deportivo Toluca | 1:2 | ||||
| 5. Round | 16/08/2020 | Deportivo Toluca | - | UANL Tigres | 3:2 | ||||
| 6. Round | 23/08/2020 | Deportivo Toluca | - | Deportivo Guadalajara | 1:0 | ||||
| 7. Round | 29/08/2020 | Puebla FC | - | Deportivo Toluca | 4:1 | ||||
| 8. Round | 04/09/2020 | Gallos Blancos | - | Deportivo Toluca | 4:1 | ||||
| 9. Round | 09/09/2020 | Deportivo Toluca | - | FC Juárez | 0:1 | ||||
| 10. Round | 13/09/2020 | CF América | - | Deportivo Toluca | 1:1 | ||||
| 11. Round | 20/09/2020 | Deportivo Toluca | - | Santos Laguna | 1:2 | |
|||
| 12. Round | 25/09/2020 | CF Pachuca | - | Deportivo Toluca | 0:0 | ||||
| 13. Round | 04/10/2020 | Deportivo Toluca | - | Cruz Azul | 2:0 | ||||
| 14. Round | 18/10/2020 | Pumas UNAM | - | Deportivo Toluca | 1:0 |  |
|||
| 15. Round | 25/10/2020 | Deportivo Toluca | - | Club Tijuana | 2:0 | ||||
| 16. Round | 31/10/2020 | Club Necaxa | - | Deportivo Toluca | 3:2 | |
|||
| 17. Round | 08/11/2020 | Deportivo Toluca | - | Club León | 2:2 | |
Ecuador