| 5. Round | 29/08/2021 | Houston Dynamo | - | Minnesota United FC | 1:2 | ||||
| 6. Round | 04/09/2021 | Houston Dynamo | - | Portland Timbers | 0:2 | ||||
| 6. Round | 12/09/2021 | Houston Dynamo | - | Austin FC | 3:0 | ||||
| 6. Round | 16/09/2021 | Los Angeles Galaxy | - | Houston Dynamo | 1:1 | ||||
| 6. Round | 19/09/2021 | Houston Dynamo | - | FC Dallas | 3:2 | ||||
| 6. Round | 26/09/2021 | Minnesota United FC | - | Houston Dynamo | 2:0 | ||||
| 6. Round | 30/09/2021 | Houston Dynamo | - | Vancouver Whitecaps | 0:0 | ||||
| 7. Round | 03/10/2021 | Sporting Kansas City | - | Houston Dynamo | 4:2 | ||||
| 7. Round | 17/10/2021 | Houston Dynamo | - | Seattle Sounders | 2:1 | ||||
| 7. Round | 21/10/2021 | Houston Dynamo | - | Los Angeles Galaxy | 0:3 | ||||
| 7. Round | 31/10/2021 | Houston Dynamo | - | Colorado Rapids | 0:1 |
USA