| 1. Round | 19/01/2008 | Club San Luis | - | UANL Tigres | 1:1 | ||||
| 2. Round | 27/01/2008 | Club Necaxa | - | Club San Luis | 1:1 |  |
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| 4. Round | 09/02/2008 | Club San Luis | - | Deportivo Toluca | 2:0 | ||||
| 5. Round | 14/02/2008 | Veracruz (old) | - | Club San Luis | 1:1 | ||||
| 6. Round | 16/02/2008 | Club San Luis | - | CF Pachuca | 2:1 | |
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| 7. Round | 24/02/2008 | Deportivo Guadalajara | - | Club San Luis | 2:2 |  |
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| 12. Round | 29/03/2008 | Club San Luis | - | Jaguares Chiapas | 0:2 | ||||
| 13. Round | 06/04/2008 | Pumas UNAM | - | Club San Luis | 2:3 | ||||
| 14. Round | 12/04/2008 | Club San Luis | - | UAG Tecos | 1:1 | ||||
| 15. Round | 20/04/2008 | Monarcas Morelia | - | Club San Luis | 1:2 | ||||
| 16. Round | 26/04/2008 | Club San Luis | - | Atlas Guadalajara | 0:0 |
USA
Mexico