| 1. Round | 08/01/2012 | Club San Luis | - | Pumas UNAM | 1:0 | ||||
| 2. Round | 14/01/2012 | Estudiantes Tecos | - | Club San Luis | 0:2 | ||||
| 3. Round | 21/01/2012 | Monarcas Morelia | - | Club San Luis | 2:0 | ||||
| 4. Round | 29/01/2012 | Club San Luis | - | CF América | 1:3 |  |
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| 5. Round | 04/02/2012 | CF Monterrey | - | Club San Luis | 3:0 | ||||
| 6. Round | 12/02/2012 | Club San Luis | - | UANL Tigres | 0:2 | ||||
| 10. Round | 11/03/2012 | Club San Luis | - | CF Pachuca | 0:0 | ||||
| 11. Round | 18/03/2012 | Puebla FC | - | Club San Luis | 0:1 | |
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| 12. Round | 25/03/2012 | Club San Luis | - | Atlante | 2:3 | ||||
| 13. Round | 31/03/2012 | Cruz Azul | - | Club San Luis | 3:1 | ||||
| 14. Round | 08/04/2012 | Club San Luis | - | Jaguares Chiapas | 2:3 | ||||
| 15. Round | 14/04/2012 | Gallos Blancos (old) | - | Club San Luis | 2:2 | ||||
| 16. Round | 21/04/2012 | Club San Luis | - | Club Tijuana | 0:1 | ||||
| 17. Round | 29/04/2012 | Deportivo Toluca | - | Club San Luis | 2:1 |
USA
Mexico