| 1. Round | 22/07/2012 | Santos Laguna | - | Club San Luis | 2:1 | ||||
| 2. Round | 29/07/2012 | Club San Luis | - | Cruz Azul | 1:2 |  |
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| 3. Round | 04/08/2012 | Monarcas Morelia | - | Club San Luis | 3:3 | ||||
| 4. Round | 12/08/2012 | Club San Luis | - | CF Monterrey | 1:1 | ||||
| 5. Round | 19/08/2012 | Club San Luis | - | Deportivo Guadalajara | 0:1 |  |
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| 6. Round | 26/08/2012 | Puebla FC | - | Club San Luis | 1:0 | ||||
| 9. Round | 23/09/2012 | Club San Luis | - | CF Pachuca | 1:0 | ||||
| 10. Round | 30/09/2012 | UANL Tigres | - | Club San Luis | 0:0 | ||||
| 12. Round | 07/10/2012 | Jaguares Chiapas | - | Club San Luis | 4:0 | ||||
| 13. Round | 14/10/2012 | Club San Luis | - | Atlante | 2:2 |
USA
Mexico