| 11. Round | 07/11/2021 | FC Differdange 03 | - | US Hostert | 1:4 | ||||
| 12. Round | 21/11/2021 | US Hostert | - | Victoria Rosport | 1:3 | ||||
| 13. Round | 28/11/2021 | CS FOLA Esch | - | US Hostert | 2:0 | ||||
| 14. Round | 05/12/2021 | US Hostert | - | UNA Strassen | 1:1 | ||||
| 15. Round | 12/12/2021 | Swift Hesperange | - | US Hostert | 0:2 | ||||
| 21. Round | 13/03/2022 | US Hostert | - | RFCU Luxemburg | 1:4 |  |
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| 23. Round | 03/04/2022 | US Hostert | - | US Mondorf | 1:1 | ||||
| 24. Round | 10/04/2022 | Etzella Ettelbruck | - | US Hostert | 1:0 | ||||
| 25. Round | 16/04/2022 | US Hostert | - | FC Differdange 03 | 0:0 | ||||
| 26. Round | 24/04/2022 | Victoria Rosport | - | US Hostert | 2:2 | ||||
| 28. Round | 08/05/2022 | UNA Strassen | - | US Hostert | 4:0 | ||||
| 30. Round | 22/05/2022 | FC Rodange 91 | - | US Hostert | 2:3 |
Poland