| 7. Round | 11/09/2021 | ŠKF Sereď | - | Tatran Liptovský Mikuláš | 2:0 | ||||
| 8. Round | 18/09/2021 | Tatran Liptovský Mikuláš | - | FK Pohronie | 5:1 |  |
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| 9. Round | 25/09/2021 | Zlaté Moravce | - | Tatran Liptovský Mikuláš | 2:2 | |
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| 10. Round | 02/10/2021 | MFK Ružomberok | - | Tatran Liptovský Mikuláš | 4:1 | ||||
| 11. Round | 15/10/2021 | Tatran Liptovský Mikuláš | - | AS Trenčín | 2:1 | ||||
| 12. Round | 24/10/2021 | Slovan Bratislava | - | Tatran Liptovský Mikuláš | 4:0 | ||||
| 13. Round | 30/10/2021 | Tatran Liptovský Mikuláš | - | FC DAC 1904 | 1:0 | ||||
| 17. Round | 04/12/2021 | FK Senica | - | Tatran Liptovský Mikuláš | 1:0 | ||||
| 18. Round | 11/12/2021 | Tatran Liptovský Mikuláš | - | ŠKF Sereď | 1:1 | |
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| 19. Round | 18/12/2021 | FK Pohronie | - | Tatran Liptovský Mikuláš | 2:2 |
Slovakia