| 4. Round | 27/09/2024 | Huracanes Izcalli | - | Santiago FC | 0:1 | ||||
| 6. Round | 12/10/2024 | Santiago FC | - | Real Zamora | 3:0 | ||||
| 8. Round | 26/10/2024 | Santiago FC | - | Club de Ciervos | 2:1 | ||||
| 9. Round | 02/11/2024 | CDM FC | - | Santiago FC | 2:0 | ||||
| 10. Round | 09/11/2024 | Santiago FC | - | Atlético Pachuca | 4:0 | ||||
| 11. Round | 16/11/2024 | Club Calor | - | Santiago FC | 0:1 | ||||
| 13. Round | 29/11/2024 | Cañoneros FC | - | Santiago FC | 0:1 |
Mexico