| 3. Round | 25/01/2025 | Cordobés FC | - | Santiago FC | 2:0 | ||||
| 6. Round | 14/02/2025 | Real Zamora | - | Santiago FC | 1:2 | ||||
| 7. Round | 22/02/2025 | Santiago FC | - | Poza Rica | 4:1 | ||||
| 8. Round | 01/03/2025 | Club de Ciervos | - | Santiago FC | 0:3 | ||||
| 9. Round | 08/03/2025 | Santiago FC | - | CDM FC | 1:1 | ||||
| 10. Round | 14/03/2025 | Atlético Pachuca | - | Santiago FC | 0:0 | ||||
| 11. Round | 22/03/2025 | Santiago FC | - | Club Calor | 2:0 |  |
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| 13. Round | 05/04/2025 | Santiago FC | - | Cañoneros FC | 2:1 |
Mexico