3. Round | 01/08/2021 | Guaraní | - | 12 de Octubre de Itauguá | 4:1 | ||||
4. Round | 07/08/2021 | Guaraní | - | Club Olimpia | 3:1 | ||||
5. Round | 15/08/2021 | Sportivo Luqueño | - | Guaraní | 1:4 | ||||
6. Round | 24/08/2021 | Guaraní | - | Libertad | 2:2 | ||||
7. Round | 30/08/2021 | River Plate | - | Guaraní | 1:5 | ||||
8. Round | 12/09/2021 | Guaraní | - | Guaireña FC | 3:0 |