| 2. Round | 25/09/2020 | Mazorqueros | - | Saltillo FC | 1:1 | ||||
| 6. Round | 25/10/2020 | Tuzos de la UAZ | - | Saltillo FC | 0:0 | ||||
| 5. Round | 31/10/2020 | Saltillo FC | - | Gavilanes de Matamoros | 0:0 | ||||
| 8. Round | 13/11/2020 | Cimarrones de Sonora II | - | Saltillo FC | 0:2 | ||||
| 7. Round | 17/11/2020 | Saltillo FC | - | Alacranes de Durango | 1:2 | ||||
| 9. Round | 21/11/2020 | Colima FC | - | Saltillo FC | 3:0 |  |
|||
| 15. Round | 06/02/2021 | Saltillo FC | - | Reboceros de La Piedad | 2:2 | ||||
| 18. Round | 06/03/2021 | Alacranes de Durango | - | Saltillo FC | 3:1 | ||||
| 19. Round | 13/03/2021 | Saltillo FC | - | Cimarrones de Sonora II | 1:0 | ||||
| 20. Round | 20/03/2021 | Saltillo FC | - | Colima FC | 0:1 | ||||
| 21. Round | 03/04/2021 | Leones Negros II | - | Saltillo FC | 3:0 | ||||
| 22. Round | 10/04/2021 | Saltillo FC | - | Tecos Fútbol Club | 2:2 |
Mexico