| 1. Round | 19/09/2020 | Alacranes de Durango | - | Atlético San Luis II | 2:0 | ||||
| 3. Round | 02/10/2020 | Saltillo FC | - | Atlético San Luis II | 1:3 | ||||
| 5. Round | 15/10/2020 | Tecos Fútbol Club | - | Atlético San Luis II | 2:0 | ||||
| 6. Round | 24/10/2020 | Atlético San Luis II | - | Mineros de Fresnillo FC | 1:0 | ||||
| 8. Round | 14/11/2020 | Atlético San Luis II | - | Colima FC | 2:0 | ||||
| 14. Round | 29/01/2021 | Atlético San Luis II | - | Saltillo FC | 2:0 | ||||
| 18. Round | 05/03/2021 | Atlético San Luis II | - | Mazorqueros | 2:1 | ||||
| 22. Round | 10/04/2021 | Tuzos de la UAZ | - | Atlético San Luis II | 1:0 |
Mexico