| 1. Round | 07/09/2024 | Santiago FC | - | Caja Oblatos | 3:0 | ||||
| 2. Round | 15/09/2024 | CD Ayense | - | Santiago FC | 1:1 | ||||
| 3. Round | 21/09/2024 | Santiago FC | - | Cordobés FC | 3:0 |  |
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| 4. Round | 27/09/2024 | Huracanes Izcalli | - | Santiago FC | 0:1 | ||||
| 5. Round | 05/10/2024 | Artesanos Metepec | - | Santiago FC | 2:1 | ||||
| 6. Round | 12/10/2024 | Santiago FC | - | Real Zamora | 3:0 | |
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| 7. Round | 19/10/2024 | Poza Rica | - | Santiago FC | 0:0 | ||||
| 8. Round | 26/10/2024 | Santiago FC | - | Club de Ciervos | 2:1 |  |
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| 9. Round | 02/11/2024 | CDM FC | - | Santiago FC | 2:0 | ||||
| 10. Round | 09/11/2024 | Santiago FC | - | Atlético Pachuca | 4:0 | |
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| 11. Round | 16/11/2024 | Club Calor | - | Santiago FC | 0:1 | ||||
| 13. Round | 29/11/2024 | Cañoneros FC | - | Santiago FC | 0:1 | |
Mexico